One of the more important and dangerous challenges, both throughout and since the end of the Cold War, has been winding down the enormous and costly stockpiles of nuclear weapons and strategic delivery systems, especially in the United States and former Soviet Union. Green Cross has been active since the mid-1990s in facilitating the safe transport, storage, and dismantlement of nuclear warheads and launch systems.

Much progress was made since the early 1970s in the bilateral SALT and START agreements between the US and USSR/Russia which have reduced stockpiles to some 10,000 nuclear warheads and bombs on each side today.Green Cross has taken part in the dismantlement process of nuclear warheads and launch systems, and worked with the US Cooperative Threat Reduction (CTR) Program and the Group of Eight Global Partnership to help Russia safely eliminate many of its nuclear-armed and -powered submarines. The Green Cross Russia regional outreach and information office in Severodvinsk in northwest Russia, for example, facilitated the dismantlement of some of the largest nuclear submarines at the Sevmash and Zvezhdochka shipyards.  Green Cross has also organized many international dialogues in Moscow, Saint Petersburg, and Washington DC to promote timely, effective, and verified nuclear weapons reductions. Related content: